论文标题
Brillouin成像用于生物学和生物医学微力学研究：从当前的最新到未来的临床翻译
Brillouin imaging for studies of micromechanics in biology and biomedicine: from current state-of-the-art to future clinical translation
论文作者
论文摘要
越来越多地认为，布里渊成像是一种强大的技术，可以在微观范围内无创测量细胞和组织的机械性能。这提供了一种空前的工具，用于研究细胞机械生物学，细胞 - 矩阵相互作用，健康和疾病条件下的组织生物力学以及其他基本生物学问题。光学硬件的最新进展尤其加速了该技术的开发，并具有越来越高的光谱分辨率和更强大的系统功能。我们设想，进一步的发展将使布里鲁因成像的翻译能够评估临床标本和样品进行疾病筛查和监测。这篇综述的目的是总结布里鲁因显微镜和成像的最新作品，并特别关注生物组织和细胞测量。将讨论关键系统和操作要求，以促进布里鲁因成像的更广泛应用，以及当前在临床和医疗应用中转换该技术的挑战。
Brillouin imaging is increasingly recognized to be a powerful technique that enables non-invasive measurement of the mechanical properties of cells and tissues on a microscopic scale. This provides an unprecedented tool for investigating cell mechanobiology, cell-matrix interactions, tissue biomechanics in healthy and disease conditions and other fundamental biological questions. Recent advances in optical hardware have particularly accelerated the development of the technique, with increasingly finer spectral resolution and more powerful system capabilities. We envision that further developments will enable translation of Brillouin imaging to assess clinical specimens and samples for disease screening and monitoring. The purpose of this review is to summarize the state-of-the-art in Brillouin microscopy and imaging with a specific focus on biological tissue and cell measurements. Key system and operational requirements will be discussed to facilitate wider application of Brillouin imaging along with current challenges for translation of the technology for clinical and medical applications.
