论文标题
多价值网络的生物型转换为布尔网络
Bisimilar Conversion of Multi-valued Networks to Boolean Networks
论文作者
论文摘要
生物网络的离散建模框架可以分为两个不同的类别：布尔和多价。尽管多价值网络更具表达能力，可以使以多个值模型建模的调节行为进行限定，但具有同等行为的自动转换为布尔网络的能力破坏了两种方法之间的基本边界。理论上研究转换过程提供了有关弥合它们之间差距的相关见解。基本上，转换旨在找到一个布尔网络，以双值估算。在本文中，我们调查了Bisiminar转换，其中布尔整数编码是可以自由修改的参数。基于此分析，我们定义一种计算方法自动从给定的多价值估算的偶发性布尔网络中推断出偶性布尔网络。
Discrete modelling frameworks of Biological networks can be divided in two distinct categories: Boolean and Multi-valued. Although Multi-valued networks are more expressive for qualifying the regulatory behaviours modelled by more than two values, the ability to automatically convert them to Boolean network with an equivalent behaviour breaks down the fundamental borders between the two approaches. Theoretically investigating the conversion process provides relevant insights into bridging the gap between them. Basically, the conversion aims at finding a Boolean network bisimulating a Multi-valued one. In this article, we investigate the bisimilar conversion where the Boolean integer coding is a parameter that can be freely modified. Based on this analysis, we define a computational method automatically inferring a bisimilar Boolean network from a given Multi-valued one.
