论文标题
2019-NCOV基因组的蛋白质结构和序列重新分析并不表示蛇作为中间宿主或其峰值蛋白插入与HIV-1之间的独特相似性
Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein insertions and HIV-1
论文作者
论文摘要
由于2019-NCOV冠状病毒的感染正在迅速发展为全球性肺炎流行，因此非常需要仔细分析其传播和细胞机制。在本报告中，我们重新分析了Ji等人最近的两个手稿中提出的计算方法和发现。 （https://doi.org/10.1002/jmv.25682）和Pradhan等人。 （https://doi.org/10.1101/2020.01.01.30.927871），得出的结论是，蛇是2019-NCOV的中间宿主，并且2019-NCOV Spike蛋白插入术具有与HIV-1的独特相似性。我们对分析的重新实施的结果，该分析使用最先进的生物信息学方法和数据库建立在大规模数据集的基础上，不支持这些手稿提出的结论。根据我们的分析和冠状病毒的现有数据，我们得出的结论是，2019-NCOV的中间宿主比蛇更可能是哺乳动物和鸟类，并且在峰值蛋白中观察到的“新插入”是自然而然地从蝙蝠冠状病毒中演变而来的。
As the infection of 2019-nCoV coronavirus is quickly developing into a global pneumonia epidemic, careful analysis of its transmission and cellular mechanisms is sorely needed. In this report, we re-analyzed the computational approaches and findings presented in two recent manuscripts by Ji et al. (https://doi.org/10.1002/jmv.25682) and by Pradhan et al. (https://doi.org/10.1101/2020.01.30.927871), which concluded that snakes are the intermediate hosts of 2019-nCoV and that the 2019-nCoV spike protein insertions shared a unique similarity to HIV-1. Results from our re-implementation of the analyses, built on larger-scale datasets using state-of-the-art bioinformatics methods and databases, do not support the conclusions proposed by these manuscripts. Based on our analyses and existing data of coronaviruses, we concluded that the intermediate hosts of 2019-nCoV are more likely to be mammals and birds than snakes, and that the "novel insertions" observed in the spike protein are naturally evolved from bat coronaviruses.
