论文标题

具有僵硬夹杂物的纤维网络的压缩加强

Compression stiffening of fibrous networks with stiff inclusions

论文作者

Shivers, Jordan L., Feng, Jingchen, van Oosten, Anne S. G., Levine, Herbert, Janmey, Paul A., MacKintosh, Fred C.

论文摘要

组织通常由嵌入纤维生物聚合物网络中的细胞组成。虽然无细胞的重构生物聚合物网络通常在应用的单轴压缩下软化,但已经观察到包括肝脏,脑和脂肪在内的各种组织在压缩时会变硬。这种压缩僵硬效果的机制尚不清楚。 Here, we demonstrate that when a material composed of stiff inclusions embedded in a fibrous network is compressed, heterogeneous rearrangement of the inclusions can induce tension within the interstitial network, leading to a macroscopic crossover from an initial bending-dominated softening regime to a stretching-dominated stiffening regime, which occurs before and independently of jamming of the inclusions.使用粗粒粒的粒子网络模型,我们首先建立了一个相图,用于在单次压缩的2和3维系统中进行压缩驱动的,拉伸为主导的应力传播和干扰。然后,我们证明,在亚静态半融合纤维网络中,刚性夹杂物的更详细的计算模型与我们粗粒模型的预测以及与实验的定性一致性表现出定量一致。

Tissues commonly consist of cells embedded within a fibrous biopolymer network. Whereas cell-free reconstituted biopolymer networks typically soften under applied uniaxial compression, various tissues, including liver, brain, and fat, have been observed to instead stiffen when compressed. The mechanism for this compression stiffening effect is not yet clear. Here, we demonstrate that when a material composed of stiff inclusions embedded in a fibrous network is compressed, heterogeneous rearrangement of the inclusions can induce tension within the interstitial network, leading to a macroscopic crossover from an initial bending-dominated softening regime to a stretching-dominated stiffening regime, which occurs before and independently of jamming of the inclusions. Using a coarse-grained particle-network model, we first establish a phase diagram for compression-driven, stretching-dominated stress propagation and jamming in uniaxially compressed 2- and 3-dimensional systems. Then, we demonstrate that a more detailed computational model of stiff inclusions in a subisostatic semiflexible fiber network exhibits quantitative agreement with the predictions of our coarse-grained model as well as qualitative agreement with experiments.

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