论文标题
第三代伽玛相机SPECT系统
Third Generation Gamma Camera SPECT System
论文作者
论文摘要
单光子发射计算机断层扫描(SPECT)是一种非侵入性成像方式,经常用于心肌灌注成像。大多数临床SPECT系统面临的最大挑战是低灵敏度,分辨率差,并且对患者的辐射剂量相对较高。致力于心脏成像的新一代系统(GE Discovery,dspect)提高了5-8倍的敏感性。这项工作的目的是研究新的Gamma摄像头设计,其中包括21个Hemi-Ellipsoid探测器,每个探测器都带有针孔准直仪,以进一步改善灵敏度,分辨率,成像时间和辐射剂量。为了评估我们的半elipsoid系统的分辨率,在点源,杆源和NCAT幻像上进行了栅极蒙特卡洛模拟。点源模拟的目的是通过比较扁平探测器系统的平均FWHM(全宽度最大最大)与弯曲的Hemi-Ellipsoid检测器系统来获得操作针孔直径。发现弯曲半elipsoid探测器的操作针孔直径为8.68mm。使用在感兴趣区域中平均间隔的重建的杆源来评估系统分辨率。将结果与文献中可用的GE发现系统的结果进行了比较。还使用数学拟人化NCAT(NURBSBATIAC TORSO)幻影评估了系统性能,并具有全(临床)剂量习得(25MCI)2分钟,并对3mci进行超低剂量习惯为5.44mins。
Single Photon Emission Computed Tomography (SPECT) is a non-invasive imaging modality, frequently used in myocardial perfusion imaging. The biggest challenges facing the majority of clinical SPECT systems are low sensitivity, poor resolution, and the relatively high radiation dose to the patient. New generation systems (GE Discovery, DSPECT) dedicated to cardiac imaging improve sensitivity by a factor of 5-8. The purpose of this work is to investigate a new gamma camera design with 21 hemi-ellipsoid detectors each with a pinhole collimator for Cardiac SPECT for further improvement in sensitivity, resolution, imaging time, and radiation dose. To evaluate the resolution of our hemi-ellipsoid system, GATE Monte-Carlo simulations were performed on point-sources, rod-sources, and NCAT phantoms. The purpose of point-source simulation is to obtain operating pinhole diameter by comparing the average FWHM (Full width half-maximum) of flat-detector system with curved hemi-ellipsoid detector system. The operating pinhole diameter for the curved hemi-ellipsoid detector was found to be 8.68mm. System resolution is evaluated using reconstructed rod-sources equally spaced within the region of interest. The results were compared with results of GE discovery system available in the literature. The system performance was also evaluated using the mathematical anthropomorphic NCAT (NURBSbased Cardiac Torso) phantom with a full (clinical) dose acquisition (25mCi) for 2 mins and an ultra-low-dose acquisition of 3mCi for 5.44mins.