论文标题
选择的微生物种群
Microbial populations under selection
论文作者
论文摘要
本章给出了最新方法的概述，以模拟和分析选择中微生物种群的演变。第一部分回顾了Lenski对大肠杆菌的长期演化实验的两个种群遗传模型，其中模型旨在解释平均适应性演变的观察到的曲线。第二部分描述了宿主病原体系统的模型，在该模型中，病原体的种群平衡了选择，迁移和突变，这是由于观察到跨宿主的HCMV（人类巨细胞病毒）遗传多样性的动机。
This chapter gives a synopsis of recent approaches to model and analyse the evolution of microbial populations under selection. The first part reviews two population genetic models of Lenski's long-term evolution experiment with Escherichia coli, where models aim at explaining the observed curve of the evolution of the mean fitness. The second part describes a model of a host-pathogen system where the population of pathogenes experiences balancing selection, migration, and mutation, as motivated by observations of the genetic diversity of HCMV (the human cytomegalovirus) across hosts.
