论文标题
女性内分泌动力学的减少模型：验证和功能变化
Reduced model for female endocrine dynamics: Validation and functional variations
论文作者
论文摘要
正常运作的月经周期需要源自卵巢和脑组织的激素之间的显着串扰。生殖激素失调可能会导致异常功能，有时甚至不育症。该内分泌系统中的固有复杂性是确定周期破坏机制的挑战，尤其是考虑到现有数学模型中的大量未知参数。我们开发了一种新的内分泌模型来限制模型复杂性，并使用未知参数的模拟分布进行模型分析。通过采用全面的模型评估，我们确定了分化正常和异常表型的机制的集合。我们还发现了一个中间表型 - 播种相对正常的激素水平和循环动力学 - 它与不规则表型分组。结果提供了有关如何仅通过激素测量结果检测到与排卵破坏相关的临床症状的见解。
A normally functioning menstrual cycle requires significant crosstalk between hormones originating in ovarian and brain tissues. Reproductive hormone dysregulation may cause abnormal function and sometimes infertility. The inherent complexity in this endocrine system is a challenge to identifying mechanisms of cycle disruption, particularly given the large number of unknown parameters in existing mathematical models. We develop a new endocrine model to limit model complexity and use simulated distributions of unknown parameters for model analysis. By employing a comprehensive model evaluation, we identify a collection of mechanisms that differentiate normal and abnormal phenotypes. We also discover an intermediate phenotype--displaying relatively normal hormone levels and cycle dynamics--that is grouped statistically with the irregular phenotype. Results provide insight into how clinical symptoms associated with ovulatory disruption may not be detected through hormone measurements alone.
