论文标题
纳米孔捕获棒状分子：定义“定向捕获半径”
Capture of rod-like molecules by a nanopore: defining an "orientational capture radius"
论文作者
论文摘要
翻译扩散系数$ d $和电泳迁移率$μ$的短杆状分子（例如dsDNA）都被电场朝向纳米孔，都应取决于其方向。由于带有带电的杆状分子倾向于在存在不均匀的电场的情况下定向，因此随着分子接近纳米孔，$ d $和$ $ $会改变，这将影响捕获过程。我们使用理论参数和Langevin Dynamics模拟进行了简化研究该问题的研究。特别是，我们引入了一个新的\ textIt {取向捕获半径}，我们将其与等效点状粒子的捕获半径进行比较，并讨论了捕获过程中的不同物理方向以及初始方向对捕获时间的影响。
Both the translational diffusion coefficient $D$ and the electrophoretic mobility $μ$ of a short rod-like molecule (such as dsDNA) that is being pulled towards a nanopore by an electric field should depend on its orientation. Since a charged rod-like molecule tends to orient in the presence of an inhomogeneous electric field, $D$ and $μ$ will change as the molecule approaches the nanopore, and this will impact the capture process. We present a simplified study of this problem using theoretical arguments and Langevin Dynamics simulations. In particular, we introduce a new \textit{orientational capture radius} which we compare to the capture radius for the equivalent point-like particle, and we discuss the different physical regimes of orientation during capture and the impact of initial orientations on the capture time.
