论文标题

尼彭(Ninepins):用点注释的核实例分割

NINEPINS: Nuclei Instance Segmentation with Point Annotations

论文作者

Yen, Ting-An, Hsu, Hung-Chun, Pati, Pushpak, Gabrani, Maria, Foncubierta-Rodríguez, Antonio, Chung, Pau-Choo

论文摘要

基于深度学习的方法正在吸引数字病理学,越来越多的出版物和挑战旨在减轻系统和详尽地分析组织幻灯片的工作。这些方法通常达到很高的精度,而需要大量注释的数据集进行训练。在专家知识至关重要的医学领域,这一要求尤其难以满足。在本文中,我们专注于细胞核分割,这通常要求经验丰富的病理学家在吉吉像素组织学图像中注释核区域。我们提出了一种算法,例如分割,该算法使用从点注释自动生成的伪标记分段,作为减轻病理学家负担的方法。使用生成的分割掩码,该提出的方法训练了悬停网络模型的修改版本以实现实例分割。实验结果表明,所提出的方法在点注释中对不准确性是可靠的,并且与经过完全注释的实例掩码训练的悬停网络比较表明,分割性能的降解并不总是暗示在诸如组织组织分类等高阶任务中的降级。

Deep learning-based methods are gaining traction in digital pathology, with an increasing number of publications and challenges that aim at easing the work of systematically and exhaustively analyzing tissue slides. These methods often achieve very high accuracies, at the cost of requiring large annotated datasets to train. This requirement is especially difficult to fulfill in the medical field, where expert knowledge is essential. In this paper we focus on nuclei segmentation, which generally requires experienced pathologists to annotate the nuclear areas in gigapixel histological images. We propose an algorithm for instance segmentation that uses pseudo-label segmentations generated automatically from point annotations, as a method to reduce the burden for pathologists. With the generated segmentation masks, the proposed method trains a modified version of HoVer-Net model to achieve instance segmentation. Experimental results show that the proposed method is robust to inaccuracies in point annotations and comparison with Hover-Net trained with fully annotated instance masks shows that a degradation in segmentation performance does not always imply a degradation in higher order tasks such as tissue classification.

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