论文标题
细胞细胞粘附对多细胞簇迁移的影响
Effects of cell-cell adhesion on migration of multicellular clusters
论文作者
论文摘要
细胞的集合在形态发生，癌症转移和伤口愈合过程中表现出连贯的迁移。在许多情况下，较大的簇分裂，较小的子群体碰撞和重新组装，并且差距不断出现。细胞水平的粘附与群集级动力学之间的连接，以及诸如迁移速度之类的群集特性的结果。在这里，我们研究了一维细胞簇的集体迁移，这些群集使用基于接触式运动的机制集体跟踪化学梯度。我们基于统计物理的晶格气体模型以及基于细胞Potts模型的更现实的框架开发了最小的描述，该模型捕获细胞形状变化和簇重排重排。在这两种情况下，我们都发现细胞具有最佳的粘附强度，可最大程度地提高群集迁移速度。最佳谈判在维持细胞电池接触和保持簇流动性之间进行了权衡，我们将簇纵横比的最大变化视为一个显示签名。我们的结果表明，中间细胞 - 细胞粘附有一个集体益处。
Collections of cells exhibit coherent migration during morphogenesis, cancer metastasis, and wound healing. In many cases, bigger clusters split, smaller sub-clusters collide and reassemble, and gaps continually emerge. The connections between cell-level adhesion and cluster-level dynamics, as well as the resulting consequences for cluster properties such as migration velocity, remain poorly understood. Here we investigate collective migration of one- and two-dimensional cell clusters that collectively track chemical gradients using a mechanism based on contact inhibition of locomotion. We develop both a minimal description based on the lattice gas model of statistical physics, and a more realistic framework based on the cellular Potts model which captures cell shape changes and cluster rearrangement. In both cases, we find that cells have an optimal adhesion strength that maximizes cluster migration speed. The optimum negotiates a tradeoff between maintaining cell-cell contact and maintaining cluster fluidity, and we identify maximal variability in the cluster aspect ratio as a revealing signature. Our results suggest a collective benefit for intermediate cell-cell adhesion.
