论文标题
粗粒DSPC脂质双层中滑小叶的流变学
Rheology of sliding leaflets in coarse-grained DSPC lipid bilayers
论文作者
论文摘要
两亲性脂质双层修改了表面的摩擦特性。特别是，与天然表面相比，测得的滑动摩擦系数显着降低。我们在这项工作中研究了DSPC（1,2-二甲酰基-SN-甘油-3-磷胆碱）脂质双层的数值粗粒模型的摩擦特性。通过不平衡的拉力拉力和松弛模拟获得了摩擦系数。特别是，我们可以访问剪切双层的瞬时粘弹性响应。发现双层机械响应显着取决于膜的物理状态，有证据支持流体中的线性反应状态，但在凝胶区域中不具有线性反应状态。
Amphiphilic lipid bilayers modify the friction properties of the surfaces on top of which they are deposited. In particular, the measured sliding friction coefficient is significantly reduced compared with the native surface. We investigate in this work the friction properties of a numerical coarse-grained model of DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine) lipid bilayer subject to longitudinal shear. The interleaflet friction coefficient is obtained from out-of-equilibrium pulling and relaxation simulations. In particular, we gain access to the transient viscoelastic response of a sheared bilayer. The bilayer mechanical response is found to depend significantly on the membrane physical state, with evidence in favor of a linear response regime in the fluid but not in the gel region.
