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The CrMnFeCoNi high-entropy alloy is highly printable and holds great potential for structural applications. However, no significant discussions on cyclic plasticity and fatigue damage in previous studies. This study provides significant insights into the link between print processes, solidification microstructure, cyclic plasticity and fatigue damage evolution in the alloy fabricated by laser powder bed fusion. Thermodynamics-based predictions (validated by scanning transmission electron microscopy (STEM) energy dispersive X-ray spectroscopy (EDX)) showed that Cr, Co and Fe partition to the core of the solidification cells, whilst Mn and Ni to the cell boundaries in all considered print parameters. Both dislocation slip and deformation twinning were found to be responsible for plastic deformation under monotonic loading. However, the former was found to be the single dominant mechanism for cyclic plasticity. The surface finish helped to substantially delay the crack initiation and cause lack-of-fusion porosity to be the main source of crack initiation. Most significantly, the scan strategies significantly affect grain arrangements and grain dimensions, leading to noticeable effects on fatigue crack propagation; in particular, the highest resistance crack propagation was seen in the meander scan strategy with 0° rotation thanks to the most columnar grains and the smallest spacing of grain boundaries along the crack propagation path.