论文标题
超越debye长度：克服下一代生物电子传感器中的电荷筛选限制
Going Beyond the Debye Length: Overcoming Charge Screening Limitations in Next-Generation Bioelectronic Sensors
论文作者
论文摘要
电子生物传感器非常适合可磁性诊断设备，因为它们可以小型化，质量产生并与电路集成在一起。不幸的是，这类平台发展的进展受到了以下事实的阻碍：从目标分子的生物样品中存在的移动离子大大降低了传感器的灵敏度。在生理条件下，所得的电双层层的厚度小于1 nm，通常假定超过此距离的电子检测实际上是不可能的。但是，一些最近描述的传感器设计策略似乎无视这种传统的智慧，以传统模型无法捕获的方式利用了电气双层的物理。在第一个策略中，通过约束双层形成的空间来减少电荷筛选。第二种策略使用外部刺激来防止双层达到平衡，从而有效地减少了电荷筛选。本文的目的是描述这些相对较新的概念，并提供理论上的见解，以实现可以使电子生物传感超出双层层的机制。如果可以进一步开发这些概念并将其转化为实用的电子生物传感器，那么我们预见了下一代诊断技术的激动人心的机会。
Electronic biosensors are a natural fit for field-deployable diagnostic devices, because they can be miniaturized, mass produced, and integrated with circuitry. Unfortunately, progress in the development of such platforms has been hindered by the fact that mobile ions present in biological samples screen charges from the target molecule, greatly reducing sensor sensitivity. Under physiological conditions, the thickness of the resulting electric double layer is less than 1 nm, and it has generally been assumed that electronic detection beyond this distance is virtually impossible. However, a few recently-described sensor design strategies seem to defy this conventional wisdom, exploiting the physics of electrical double layers in ways that traditional models do not capture. In the first strategy, charge screening is decreased by constraining the space in which double layers can form. The second strategy uses external stimuli to prevent double layers from reaching equilibrium, thereby effectively reducing charge screening. The goal of this article is to describe these relatively new concepts, and to offer theoretical insights into mechanisms that may enable electronic biosensing beyond the double-layer. If these concepts can be further developed and translated into practical electronic biosensors, we foresee exciting opportunities for the next generation of diagnostic technologies.
