论文标题

呼气变异性指数(EVI)与患有呼吸道症状的婴儿的哮喘风险,喘息性和肺功能有关

Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms

论文作者

Seppä, Ville-Pekka, Gracia-Tabuenca, Javier, Kotaniemi-Syrjänen, Anne, Malmström, Kristiina, Hult, Anton, Pelkonen, Anna, Mäkelä, Mika J., Viik, Jari, Malmberg, L. Pekka

论文摘要

复发性呼吸道症状在婴儿中很常见,但肺功能测试的缺乏适合在婴儿中常规使用是一个公认的临床问题。在这项研究中,我们评估了在睡眠期间使用阻抗验尸(IP)在家庭睡眠期间测量的潮汐呼吸变异性(呼气变异性指数,EVI),作为36名婴儿(平均年龄12.8 [6-23个月)的较低气道阻塞的标记,并带有呼吸道呼吸症状。 EVI降低与肺部功能较低(VMAXFRC),哮喘风险较高和阻塞性症状有关,但与鼻充血无关。使用IP测量的EVI是婴儿肺功能测试的潜在技术。

Recurrent respiratory symptoms are common in infants but the paucity of lung function tests suitable for routine use in infants is a widely acknowledged clinical problem. In this study we evaluated tidal breathing variability (expiratory variability index, EVI) measured at home during sleep using impedance pneumography (IP) as a marker of lower airway obstruction in 36 infants (mean age 12.8 [range 6-23] months) with recurrent respiratory symptoms. Lowered EVI was associated with lower lung function (VmaxFRC), higher asthma risk, and obstructive symptoms, but not with nasal congestion. EVI measured using IP is a potential technique for lung function testing in infants.

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