论文标题
在合作对齐细胞簇中增强了持久性和集体迁移
Enhanced persistence and collective migration in cooperatively aligning cell clusters
论文作者
论文摘要
大多数细胞具有移动的能力。单独或集体，这使他们可以适应，重新排列并探索周围环境。到目前为止，这种运动过程的生物物理表征主要集中在两种限制案例上：一方面单细胞运动性，以及汇合组织的动力学，例如上皮细胞。由相对较少的细胞组成的簇的内在趋势中，作为一个连贯的单元移动的关注较少。但是，如此小的簇在发育中与癌症转移非常相关。在这项工作中，我们使用细胞POTTS模型和分析活性物质理论来了解小细胞簇的运动如何随N（簇中的细胞数量）而变化。 Modeling and theory reveal our two main findings: Cluster persistence time increases with N while the intrinsic diffusivity decreases with N. We discuss a number of settings in which the motile properties of more complex clusters can be analytically understood, revealing that the focusing effects of small-scale cooperation and cell-cell alignment can overcome the increased bulkiness and internal disorder of multicellular clusters to enhance overall migrational efficacy.我们证明了小群集集体杜拉氏菌的增强，与单个细胞相比，它显示出更有效地进行的。我们的结果可能会为单细胞和大规模集体运动之间的联系提供一些新的见解，并可能指向小型肿瘤细胞簇增强转移潜力的生物物理起源。
Most cells possess the capacity to locomote. Alone or collectively, this allows them to adapt, to rearrange, and to explore their surroundings. The biophysical characterization of such motile processes, in health and disease, has so far focused mostly on two limiting cases: single-cell motility on the one hand, and the dynamics of confluent tissues such as the epithelium on the other. The in-between regime of clusters, composed of relatively few cells, moving as a coherent unit has received less attention. Such small clusters are, however, deeply relevant in development but also in cancer metastasis. In this work, we use cellular Potts models and analytical active matter theory to understand how the motility of small cell clusters changes with N, the number of cells in the cluster. Modeling and theory reveal our two main findings: Cluster persistence time increases with N while the intrinsic diffusivity decreases with N. We discuss a number of settings in which the motile properties of more complex clusters can be analytically understood, revealing that the focusing effects of small-scale cooperation and cell-cell alignment can overcome the increased bulkiness and internal disorder of multicellular clusters to enhance overall migrational efficacy. We demonstrate this enhancement for small-cluster collective durotaxis, which is shown to proceed more effectively than for single cells. Our results may provide some novel insights into the connection between single-cell and large-scale collective motion and may point the way to the biophysical origins of the enhanced metastatic potential of small tumor cell clusters.
