论文标题

无症状的个体在复杂网络中无症状在199大流行中的作用

The Role of Asymptomatic Individuals in the COVID-19 Pandemic via Complex Networks

论文作者

Stella, Leonardo, Martínez, Alejandro Pinel, Bauso, Dario, Colaneri, Patrizio

论文摘要

最近的血清阳性研究试图估计受COVID-19的无症状病例的实际数量。了解这些感染的影响以防止第二波的影响至关重要。这项研究旨在通过复杂的网络对人口的相互作用进行建模,并阐明意大利本地化控制措施在9月中旬开放的有效性。给出了流行病学预测模型的表述:使用该模型的优势在于,由于与这两种类别的感染者的相互作用被分别捕获,因此可以区分无症状和有症状的病例,并允许对无症状案例的影响进行研究。然后,通过Watts-Strogatz复杂网络将该模型扩展到结构化的非官方版本,该网络被广泛采用,以建模社会相互作用,因为它拥有小型世界属性。最后,给出了一项关于意大利情况的案例研究:首先,均质模型用于将官方数据与ISTAT最近的血清阳性研究数据进行比较;其次,鉴于9月中旬返回学校,进行了区域研究。这项研究的结果强调了协调适当控制措施的部署的重要性,这些措施考虑了无症状感染的作用,尤其是在年轻人中,以及意大利的区域间连通性。

Recent seroprevalence studies have tried to estimate the real number of asymptomatic cases affected by COVID-19. It is of paramount importance to understand the impact of these infections in order to prevent a second wave. This study aims to model the interactions in the population by means of a complex network and to shed some light on the effectiveness of localised control measures in Italy in relation to the school opening in mid-September. The formulation of an epidemiological predictive model is given: the advantage of using this model lies in that it discriminates between asymptomatic and symptomatic cases of COVID-19 as the interactions with these two categories of infected individuals are captured separately, allowing for a study on the impact of asymptomatic cases. This model is then extended to a structured nonhomogeneous version by means of the Watts-Strogatz complex network, which is adopted widely to model societal interactions as it holds the small world property. Finally, a case study on the situation in Italy is given: first the homogeneous model is used to compare the official data with the data of the recent seroprevalence study from Istat; second, in view of the return to school in mid-September, a study at regional level is conducted. The results of this study highlight the importance of coordinating the deployment of appropriate control measures that take into account the role of asymptomatic infections, especially in younger individuals, and inter-regional connectivity in Italy.

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