论文标题
脂质双层中超长链脂肪酸的构象：分子动力学研究
Conformation of ultra-long-chain fatty acid in lipid bilayer: Molecular dynamics study
论文作者
论文摘要
超长的链脂肪酸（ULCFA）在限制性组织（例如视网膜，睾丸和皮肤）中生物合成。通过分子动力学模拟研究了单个ULCFA的构象，其中SN-1不饱和链具有32碳链具有32碳，在三种无张力的无磷脂双层中。发现ULCFA的超长尾巴在两个传单之间翻转，并在伸长的伸长率之间波动，向相对的小叶，位于两个小叶之间，然后向后转。随着相反小叶中脂质的数量比增加，在所有三种情况下，细长形状的比率均线性降低。因此，Ulcfas可以感觉到两个传单之间的密度差异并响应这些变化。
Ultra-long-chain fatty acids (ULCFAs) are biosynthesized in the restricted tissues such as retina, testis, and skin. The conformation of a single ULCFA, in which the sn-1 unsaturated chain has 32 carbons, in three types of tensionless phospholipid bilayers is studied by molecular dynamics simulations. It is found that the ultra-long tail of the ULCFA flips between two leaflets and fluctuates among an elongation into the opposite leaflet, lying between two leaflets, and turning back. As the number ratio of lipids in the opposite leaflet increases, the ratio of the elongated shape linearly decreases in all three cases. Thus, ULCFAs can sense the density differences between the two leaflets and respond to these changes.
