论文标题
使用元音失真措施对明显的亨廷顿疾病进行分类
Classification of Manifest Huntington Disease using Vowel Distortion Measures
论文作者
论文摘要
亨廷顿病(HD)是一种致命的常染色体显性神经认知疾病,会引起认知障碍,神经精神症状和运动能力受损(例如步态,语音,语音)。由于其渐进性,高清治疗需要持续对症状进行临床监测。导致HD的基因突变的个体可能会在从premifest到明显HD的过程中表现出一系列语音症状。区分前命中率和明显的HD是一个重要但正在研究的问题,因为这种区别标志着需要增加治疗的需求。基于语音的被动监测有可能通过不断跟踪表现症状来增强临床评估。在这项工作中,我们介绍了如何衡量连接语音变化以区分前命中率和明显HD的第一个演示。为此,我们专注于高清:元音失真的关键语音症状。我们介绍了一组元音功能,我们从连接的语音中提取了这些功能。我们表明,我们的元音功能可以以87%的精度区分前命中率和明显的高清。
Huntington disease (HD) is a fatal autosomal dominant neurocognitive disorder that causes cognitive disturbances, neuropsychiatric symptoms, and impaired motor abilities (e.g., gait, speech, voice). Due to its progressive nature, HD treatment requires ongoing clinical monitoring of symptoms. Individuals with the gene mutation which causes HD may exhibit a range of speech symptoms as they progress from premanifest to manifest HD. Differentiating between premanifest and manifest HD is an important yet understudied problem, as this distinction marks the need for increased treatment. Speech-based passive monitoring has the potential to augment clinical assessments by continuously tracking manifestation symptoms. In this work we present the first demonstration of how changes in connected speech can be measured to differentiate between premanifest and manifest HD. To do so, we focus on a key speech symptom of HD: vowel distortion. We introduce a set of vowel features which we extract from connected speech. We show that our vowel features can differentiate between premanifest and manifest HD with 87% accuracy.