论文标题
分别获得实验测量的关节构象分布的推断
Inference of joint conformational distributions from separately-acquired experimental measurements
论文作者
论文摘要
许多生物分子具有柔性结构，需要其构象的分布估计。获取分布数据的实验通常分别测量标签对，丢失了有关关节分布的信息。在估计构象集合时，这些数据被假定独立。我们开发了一种方法来估算单独获取的测量结果的真实关节分布，并在两个生物系统上进行测试。该方法准确地重现了已知并产生有关复杂构象合并的可测试预测的关节分布。
Many biomolecules have flexible structures, requiring distributional estimates of their conformations. Experiments to acquire distributional data typically measure pairs of labels separately, losing information on the joint distribution. These data are assumed independent when estimating the conformational ensemble. We developed a method to estimate the true joint distribution from separately acquired measurements, testing it on two biological systems. This method accurately reproduces the joint distribution where known and generates testable predictions about complex conformational ensembles.
