论文标题
抑制神经元在关键和超临界活动的时间相关性中的作用
Role of inhibitory neurons in temporal correlations of critical and supercritical spontaneous activity
论文作者
论文摘要
实验和数值结果表明，可以将大脑视为接近临界点的系统，如各种不同系统和模型中相关数量的无标度分布所证实。在不同，健康和病理状况下，注意到了对脑活动的时间相关功能的研究。在这里，我们通过具有短期和长期可塑性的模型进行此分析，该模型在实验中发现了兴奋性和抑制性神经元的不同恢复速率的新特征。我们证明了抑制性神经元在超临界状态下起的重要作用：我们检测到相关衰减的意外振荡行为，其频率取决于抑制性神经元的分数及其连通性程度。可以通过观察到活动爆发变得更加频繁，并且随着抑制变得更加相关的幅度较小的观察结果可以合理地化。
Experimental and numerical results suggest that the brain can be viewed as a system acting close to a critical point, as confirmed by scale-free distributions of relevant quantities in a variety of different systems and models. Less attention has received the investigation of the temporal correlation functions in brain activity in different, healthy and pathological, conditions. Here we perform this analysis by means of a model with short and long-term plasticity which implements the novel feature of different recovery rates for excitatory and inhibitory neurons, found experimentally. We evidence the important role played by inhibitory neurons in the supercritical state: We detect an unexpected oscillatory behaviour of the correlation decay, whose frequency depends on the fraction of inhibitory neurons and their connectivity degree. This behaviour can be rationalized by the observation that bursts in activity become more frequent and with a smaller amplitude as inhibition becomes more relevant.
