论文标题
假设订单限制的k剂量组比例的比较与阴性对照：威廉姆斯型测试与封闭测试程序
Comparisons of proportions in k dose groups against a negative control assuming order restriction: Williams-type test vs. closed test procedures
论文作者
论文摘要
在渐近通用线性模型中考虑比较的比较比值比为效应大小。当将几种剂量与假定订单限制的对照进行比较时，可以使用Williams型趋势测试。作为替代方案，考虑了封闭测试方法的两个变体，一种是使用分区假设中的全球威廉姆斯检验的一种变体，一种是成对对比的。在权力和简单性方面，它们的优势得到了证明。提供了相关的R代码。
The comparison of proportions is considered in the asymptotic generalized linear model with the odds ratio as effect size. When several doses are compared with a control assuming an order restriction, a Williams-type trend test can be used. As an alternative, two variants of the closed testing approach are considered, one using global Williams-tests in the partition hypotheses, one with pairwise contrasts. Their advantages in terms of power and simplicity are demonstrated. Related R-code is provided.
