论文标题

通过脉动流动在微流体阵列中缓解堵塞

Clog mitigation in a microfluidic array via pulsatile flows

论文作者

Dincau, Brian, Tang, Connor, Dressaire, Emilie, Sauret, Alban

论文摘要

堵塞是在悬浮液运输过程中遇到的常见障碍物,代表了整个应用中的巨大能量和材料成本,包括水纯化,灌溉,生物制药加工和含水层补给。与稳定流动相比,脉冲压力驱动的流量可以帮助减轻堵塞。在这里,我们通过实验研究脉动振幅$ 0.25 \,p_0 \leqΔp\ leq leq 1.25 \,p_0 $,其中$ p_0 $是平均压力,脉冲频率$ 10^{ - 3} \,3} \,{\ rm hz} \ rm hz} \ rm hz} \ leq leq leq leq leq leq leq leq leq leq f \ leq f \ - 使用胶体颗粒的稀悬浮液在平行通道的微流体阵列中缓解堵塞的Hz} $。阵列几何形状代表了经典滤波器,其平行孔会随着时间的流逝而堵塞,产生了一个继续生长并可以与其他孔相互作用的过滤蛋糕。我们将流速测量结果与孔尺度的直接可视化结合在一起,以将观察到的堵塞动力学与流速变化相关联。我们观察到,与稳定流量相比,所有脉动幅度均为$ 0.1 $ Hz的产量增加吞吐量。受动态剪切环境的约束时,颗粒的重排可能会延迟孔隙的堵塞,甚至可以清除现有的堵塞。但是,由于脉冲时间尺度与与堵塞的时间表和与堵塞的时间表相比,因此,此优势大幅降低了$ 10^{ - 2} $ Hz,以$ 10^{ - 3} $ Hz消失,并消失。本研究表明,脉冲流是在孔隙和系统尺度上延迟堵塞的一种有前途的方法。

Clogging is a common obstacle encountered during the transport of suspensions and represents a significant energy and material cost across applications, including water purification, irrigation, biopharmaceutical processing, and aquifer recharge. Pulsatile pressure-driven flows can help mitigate clogging when compared to steady flows. Here, we study experimentally the influence of the amplitude of pulsation $0.25\,P_0 \leq δP \leq 1.25\,P_0$, where $P_0$ is the mean pressure, and of the frequency of pulsation $10^{-3}\,{\rm Hz} \leq f \leq 10^{-1}\,{\rm Hz}$ on clog mitigation in a microfluidic array of parallel channels using a dilute suspension of colloidal particles. The array geometry is representative of a classical filter, with parallel pores that clog over time, yielding a filter cake that continues to grow and can interact with other pores. We combine flow rate measurements with direct visualizations at the pore scale to correlate the observed clogging dynamics with the changes in flow rate. We observe that all pulsatile amplitudes at $0.1$ Hz yield increased throughput compared to steady flows. The rearrangement of particles when subject to a dynamic shear environment can delay the clogging of a pore or even remove an existing clog. However, this benefit is drastically reduced at $10^{-2}$ Hz and disappears at $10^{-3}$ Hz as the pulsatile timescale becomes too large compared to the timescale associated with the clogging and the growth of the filter cakes in this system. The present study demonstrates that pulsatile flows are a promising method to delay clogging at both the pore and system scale.

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