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The Weak Gravity Conjecture holds that in a theory of quantum gravity, any gauge force must mediate interactions stronger than gravity for some particles. This statement has surprisingly deep and extensive connections to many different areas of physics and mathematics. Several variations on the basic conjecture have been proposed, including statements that are much stronger but are nonetheless satisfied by all known consistent quantum gravity theories. We review these related conjectures and the evidence for their validity in the string theory landscape. We also review a variety of arguments for these conjectures, which tend to fall into two categories: qualitative arguments which claim the conjecture is plausible based on general principles, and quantitative arguments for various special cases or analogues of the conjecture. We also outline the implications of these conjectures for particle physics, cosmology, general relativity, and mathematics. Finally, we highlight important directions for future research.