论文标题

由三态基因产生随机mRNA

Stochastic mRNA production by a three-state gene

论文作者

Rubinstein, Boris, Unruh, Jay, Zeitlinger, Julia

论文摘要

我们考虑了一个由三个可能的状态中存在的基因的动力学控制的mRNA产生模型 - 不活跃,有现状和活跃。相邻状态之间的过渡由以相应的/OFF速率为特征的随机过程控制。仅当基因处于活性状态时,才会产生mRNA,我们还考虑导致其死亡的mRNA变性。

We consider a model of mRNA production governed by the dynamics of a gene that exists in three possible states -- inactive, poised and active. The transitions between the adjacent states are controlled by stochastic processes characterized by corresponding on/off rates. mRNA is produced only when the gene is in active state and we also consider mRNA denaturation leading to its death.

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