论文标题
人类有丝分裂染色体振荡的张力锁定控制
Tension-clock control of human mitotic chromosome oscillations
论文作者
论文摘要
在细胞分裂期间，（姐妹）染色体在整个平面中进行了近似的锯齿振荡。实验数据表明，这些振荡是通过内部张力来调节的。我们提出了一个依赖时间的张力阈值模型，该模型表现出三种稳定的周期性解决方案，并且可以通过半分析生成相图。扩散噪声的结合可重现现实的振荡，并具有逼真的时期，幅度，并重现了这对夫妇的任何一个姐妹都可以首先切换方向的观察结果。
During cell division paired (sister) chromosomes are observed to perform approximate saw-tooth oscillations across the cell mid-plane. Experimental data suggests that these oscillations are regulated through intersister tension. We propose a time dependent tension threshold model that exhibits three stable periodic solutions and the phase diagram can be generated semi-analytically. Incorporation of diffusive noise reproduces realistic oscillations, with realistic periods, amplitudes and reproducing the observation that either sister of the pair can switch direction first.
