论文标题
微波手性成像，用于早期诊断神经系统退行性疾病
Microwave Chirality Imaging for the Early Diagnosis of Neurological Degenerative Diseases
论文作者
论文摘要
我们提出了一个系统来可视化大脑中蛋白质的手性，这将有助于诊断体内神经系统变性疾病。这些神经系统退化性疾病通常与一些标记蛋白一起出现。通过纳米颗粒灌输和超材料技术，假定标记蛋白的手性作用在微波状态下表现出来。因此，通过检测交叉极化的传播，我们可以检测到旋转微波极化角的手性。我们开发了一种数值方法来模拟手性（双性异性）材料上的电磁反应。然后，用数值头幻影进行数值实验。可以通过扫描天线对来达到交叉透射幅度的图。成像结果与手性材料的分布非常匹配。这表明所提出的方法将能够使用微波对神经退行性疾病进行体内成像。
We propose a system to visualize the chirality of the protein in brains, which would be helpful to diagnose early neurological degenerative diseases in vivo. These neurological degenerative diseases often occur along with some mark proteins. By nanoparticle instilling and metamaterial technique, the chiral effect of the mark proteins is assumed to be manifest in microwave regime. Therefore, by detecting the transmission of cross-polarization, we could detect the chirality that rotates the microwave polarization angle. We developed a numerical method to simulate the electromagnetic response upon chiral (bi-isotropic) material. Then a numerical experiment was conduct with a numerical head phantom. A map of cross-polarized transmission magnitude can be reached by sweeping the antenna pair. The imaging results matches well with the distribution of chiral materials. It suggests that the proposed method would be capable of in vivo imaging of neurological degenerative disease using microwaves.
