论文标题
在动态细胞内网络上进行扩散运输时间的快速求解器
Fast solver for diffusive transport times on dynamic intracellular networks
论文作者
论文摘要
细胞中颗粒的转运受其遍历局部目标区域或反应伴侣的细胞内网络的特性的影响。此外，考虑到许多细胞内结构的快速营业额，了解网络结构的时间变化如何影响扩散传输至关重要。在这项工作中，我们使用网络理论来表征跨尺度的复杂细胞内生物学环境。我们开发了一种有效的计算方法，以计算平均第一个通道时间，以模拟从荧光显微镜成像中提取的二维平面网络扩散的粒子。我们首先在合成网络的背景下基准该方法，然后将其应用于内质网络网络中的活细胞数据。
The transport of particles in cells is influenced by the properties of intracellular networks they traverse while searching for localized target regions or reaction partners. Moreover, given the rapid turnover in many intracellular structures, it is crucial to understand how temporal changes in the network structure affect diffusive transport. In this work, we use network theory to characterize complex intracellular biological environments across scales. We develop an efficient computational method to compute the mean first passage times for simulating a particle diffusing along two-dimensional planar networks extracted from fluorescence microscopy imaging. We first benchmark this methodology in the context of synthetic networks, and subsequently apply it to live-cell data from endoplasmic reticulum tubular networks.
