论文标题
可逆电穿孔的模型，将药物输送到患病组织中
A model for reversible electroporation to deliver drugs into diseased tissues
论文作者
论文摘要
通过电穿孔输送药物可能对治疗人体内不同类型的患病组织非常有益。在这项工作中，提出了可逆组织电穿孔的数学模型，用于将药物注入患病细胞中。该模型强调了将药物注入点源的组织边界。研究了通过细胞外空间从组织边界中的药物损失。将多个脉冲用于将足够量的药物输送到靶细胞中。建模物理环境的一组微分方程是数值求解的。该模型根据孔隙分数系数和药物渗透性获得传质系数。它控制着从细胞外到细胞内空间的药物转运。捕获整个组织中的药物穿透以应用不同的脉冲。这项研究突出了对药物浓度的边界影响。主张的模型能够对细胞进行均匀的药物运输，从而完全治疗受影响的组织。该模型可以通过避免长期和昂贵的体内和体外实验来优化临床实验。
Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues within the human body. In this work, a mathematical model of reversible tissue electroporation is presented for injecting drug into the diseased cells. The model emphasizes the tissue boundary where the drug is injected as a point source. Drug loss from the tissue boundaries through extracellular space is studied. Multiple pulses are applied to deliver a sufficient amount of drug into the targeted cells. The set of differential equations that model the physical circumstances are solved numerically. This model obtains a mass transfer coefficient in terms of pore fraction coefficient and drug permeability. It controls the drug transport from extracellular to intracellular space. The drug penetration throughout the tissue is captured for the application of different pulses. The boundary effects on drug concentration are highlighted in this study. The advocated model is able to perform homogeneous drug transport into the cells so that the affected tissue is treated completely. This model can be applied to optimize clinical experiments by avoiding the lengthy and costly in vivo and in vitro experiments.
