论文标题
蛋白质几何形状，功能和突变
Protein Geometry, Function and Mutation
论文作者
论文摘要
这项对数学家的调查总结了作者在蛋白质几何和蛋白质功能方面的几项作品，通常在病毒糖蛋白上应用，特别是SARS-COV-2病毒的尖峰糖蛋白。绘制了背景生物学和生物物理学。这种工作体系在一个假设中达到顶点，即蛋白二级结构调节突变，骨干氢键在关键区域实现以避免突变，并从其他区域消失以实现它。
This survey for mathematicians summarizes several works by the author on protein geometry and protein function with applications to viral glycoproteins in general and the spike glycoprotein of the SARS-CoV-2 virus in particular. Background biology and biophysics are sketched. This body of work culminates in a postulate that protein secondary structure regulates mutation, with backbone hydrogen bonds materializing in critical regions to avoid mutation, and disappearing from other regions to enable it.
