论文标题
受体活性的切换时间尺度对大肠杆菌趋化性性能的影响
Effect of switching time scale of receptor activity on chemotactic performance of Escherichia coli
论文作者
论文摘要
在大肠杆菌的趋化运动中，跨膜化学感受器在活动状态和非活性状态之间的转换是信号通路的最重要步骤之一。我们研究了此切换时间尺度对细胞趋化性性能的影响。我们通过细胞的趋化漂移速度来量化性能。我们在详细的理论模型上进行的广泛数值模拟表明，随着活动切换速率的增加，漂移速度增加，然后饱和。我们的数据还表明，下坡运行的平均持续时间随切换速率而大大降低，而上坡运行的平均持续时间相对较慢。我们从沿着上坡和下坡轨迹的活动时间变化来解释这种影响。我们表明，对于大小切换率，活动变化的性质在下坡运行中表现出质量不同的行为，但沿着上坡运行的行为相似。这会导致下坡运行持续时间对开关速率和上坡运行持续时间相对较轻的依赖性的依赖性更强。
In the chemotactic motion of Escherichia coli, the switching of transmembrane chemoreceptors between active and inactive states is one of the most important steps of the signaling pathway. We study the effect of this switching time-scale on the chemotactic performance of the cell. We quantify performance by the chemotactic drift velocity of the cell. Our extensive numerical simulations on a detailed theoretical model show that as the activity switching rate increases, the drift velocity increases and then saturates. Our data also show the mean duration of a downhill run decreases strongly with the switching rate, while that of an uphill run decreases relatively slowly. We explain this effect from temporal variation of activity along uphill and downhill trajectories. We show that for large and small switching rates the nature of activity variation show qualitatively different behaviors along a downhill run but similar behavior along an uphill run. This results in a stronger dependence of downhill run duration on the switching rate and relatively milder dependence for uphill run duration.
