论文标题
在DBS手术过程中，无监督的丘脑下核子核的检测和歧管学习
Unsupervised Detection of Sub-Territories of the Subthalamic Nucleus During DBS Surgery with Manifold Learning
论文作者
论文摘要
储层计算是预测湍流的有力工具，其简单的架构具有处理大型系统的计算效率。然而，其实现通常需要完整的状态向量测量和系统非线性知识。我们使用非线性投影函数将系统测量扩展到高维空间，然后将其输入到储层中以获得预测。我们展示了这种储层计算网络在时空混沌系统上的应用，该系统模拟了湍流的若干特征。我们表明，使用径向基函数作为非线性投影器，即使只有部分观测并且不知道控制方程，也能稳健地捕捉复杂的系统非线性。最后，我们表明，当测量稀疏、不完整且带有噪声，甚至控制方程变得不准确时，我们的网络仍然可以产生相当准确的预测，从而为实际湍流系统的无模型预测铺平了道路。
During Deep Brain Stimulation(DBS) surgery for treating Parkinson's disease, one vital task is to detect a specific brain area called the Subthalamic Nucleus(STN) and a sub-territory within the STN called the Dorsolateral Oscillatory Region(DLOR). Accurate detection of the STN borders is crucial for adequate clinical outcomes. Currently, the detection is based on human experts, guided by supervised machine learning detection algorithms. Consequently, this procedure depends on the knowledge and experience of particular experts and on the amount and quality of the labeled data used for training the machine learning algorithms. In this paper, to circumvent the dependence and bias caused by the training data, we present a data-driven unsupervised method for detecting the STN and the DLOR during DBS surgery. Our method is based on an agnostic modeling approach for general target detection tasks. Given a set of measurements, we extract features and propose a variant of the Mahalanobis distance between these features. We show theoretically that this distance enhances the differences between measurements with different intrinsic characteristics. Then, we incorporate the new features and distances into a manifold learning method, called Diffusion Maps. We show that this method gives rise to a representation that is consistent with the underlying factors that govern the measurements. Since the construction of this representation is carried out without rigid modeling assumptions, it can facilitate a wide range of detection tasks; here, we propose a specification for the STN and DLOR detection tasks. We present detection results on 25 sets of measurements recorded from 16 patients during surgery. Compared to a competing supervised algorithm based on a Hidden Markov Model, our unsupervised method demonstrates similar results in the STN detection task and superior results in the DLOR detection task.
