论文标题

关于卡莱尔的方法不正确用于二分法变量

On the incorrect use of Carlisle's method for dichotomous variables

论文作者

Tausk, Daniel V.

论文摘要

2017年,J。B。Carlisle提出了一种基于对治疗组之间报告的基线数据的比较,在随机对照试验中提出了一种欺诈检测方法。尽管卡莱尔仅将该方法用于连续变量,但一些作者最近对二分法变量的方法进行了天真的适应。我们解释了为什么这种适应导致p值通过数量级错误的p值,而我们为校正该方法做出了一个简单的具体建议。

In 2017, J. B. Carlisle has proposed a method for fraud detection in randomized controlled trials based on a comparison of reported baseline data between treatment groups. While Carlisle has only used the method for continuous variables, some authors have recently employed a naive adaption of the method for dichotomous variables. We explain why such adaptation leads to p-values that are wrong by orders of magnitude and we make a simple concrete proposal for correction of the method.

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