论文标题
在X射线自由电子激光器上确定的tick传播脑炎病毒的结构。模拟
The structure of Tick-borne Encephalitis virus determined at X-Ray Free-Electron Lasers. Simulations
论文作者
论文摘要
X射线自由电子激光器（XFEL）对病毒结构的研究吸引了近几十年来更多的关注。此类实验基于在生物样品上飞秒X射线脉冲衍射后在检测器上测得的二维衍射模式的收集。为了在欧洲XFEL上准备实验，我们模拟了具有不同参数的tick传播脑炎病毒（TBEV）的衍射数据，并确定了它们的最佳值。按照建立良好的数据处理管道的必要步骤，获得了TBEV的结构，并证明了使用的方法的效率。
The study of the structure of viruses by X-ray free-electron lasers (XFEL) attracts more attention in recent decades. Such experiments are based on the collection of two-dimensional diffraction patterns measured at the detector after diffraction of femtosecond X-ray pulses on biological samples. In order to prepare the experiment at the European XFEL we simulated the diffraction data for the tick-borne encephalitis virus (TBEV) with different parameters and identified their optimal values. Following necessary steps of a well-established data processing pipeline, the structure of TBEV was obtained and the efficiency of the used methods was demonstrated.
