论文标题
空间运动校正和UTERO胎儿fMRI的迭代重建
Spatio-temporal motion correction and iterative reconstruction of in-utero fetal fMRI
论文作者
论文摘要
静止状态功能磁共振成像（fMRI）是一种用于研究子宫内大脑功能发育的强大成像技术。但是，胎儿的不可预测和过度运动限制了其临床适用性。先前的研究主要集中在对运动参数的准确估计上，该运动参数在每个单个时间范围内采用单个步骤3D插值，以恢复无运动4D fMRI图像。仅使用来自3D空间社区的信息忽略了fMRI的时间结构和来自相邻时间点的有用信息。在这里，我们提出了一种基于运动散射fMRI切片的四维迭代重建的新技术。与常规3D插值方法相比，对实际临床胎儿FMRI数据的拟议方法的定量评估表明，重建质量的提高。
Resting-state functional Magnetic Resonance Imaging (fMRI) is a powerful imaging technique for studying functional development of the brain in utero. However, unpredictable and excessive movement of fetuses have limited its clinical applicability. Previous studies have focused primarily on the accurate estimation of the motion parameters employing a single step 3D interpolation at each individual time frame to recover a motion-free 4D fMRI image. Using only information from a 3D spatial neighborhood neglects the temporal structure of fMRI and useful information from neighboring timepoints. Here, we propose a novel technique based on four dimensional iterative reconstruction of the motion scattered fMRI slices. Quantitative evaluation of the proposed method on a cohort of real clinical fetal fMRI data indicates improvement of reconstruction quality compared to the conventional 3D interpolation approaches.
