论文标题
精子游泳精度的热力学极限
Thermodynamic limits of sperm swimming precision
论文作者
论文摘要
精子游泳对于在性质和辅助生殖技术中施肥至关重要。对精子动力学进行建模涉及弹性,流体动力学,内部活性力和平衡噪声。在这里,我们在实验上证明了能量耗散对精子跳动波动的相关性。对于每个机动单元,我们重建了两个主尾巴空间模式的时间进化,该空间模式共同追踪一个噪声限制周期,其特征在于最大级别的精度$ p_ {max} $。我们的结果表明$ p_ {max} \ sim 10^2 s^{ - 1} $,非常接近鞭毛的动力蛋白分子电动机的估计精度,鞭毛是根据热力学不确定性关系而受其能量耗散率的限制。氧气剥夺下的进一步实验表明,$ p_ {max} $随着能量消耗而衰减,因为它是单个分子运动的发生的。可以通过猜测动力蛋白电动机的构象变化之间的高度协调来解释这两个观察结果。该猜想得到了一个理论模型的支持,用于击败由电动机集合驱动的理想鞭毛,包括电动机最近的邻居耦合$ k $:当$ k $很小时,大鞭毛的精度比单电动机高得多。相反,当$ k $很大时,两者变得可比。
Sperm swimming is crucial to fertilise the egg, in nature and in assisted reproductive technologies. Modelling the sperm dynamics involves elasticity, hydrodynamics, internal active forces, and out-of-equilibrium noise. Here we demonstrate experimentally the relevance of energy dissipation for sperm beating fluctuations. For each motile cell, we reconstruct the time-evolution of the two main tail's spatial modes, which together trace a noisy limit cycle characterised by a maximum level of precision $p_{max}$. Our results indicate $p_{max} \sim 10^2 s^{-1}$, remarkably close to the estimated precision of a dynein molecular motor actuating the flagellum, which is bounded by its energy dissipation rate according to the Thermodynamic Uncertainty Relation. Further experiments under oxygen deprivation show that $p_{max}$ decays with energy consumption, as it occurs for a single molecular motor. Both observations can be explained by conjecturing a high level of coordination among the conformational changes of dynein motors. This conjecture is supported by a theoretical model for the beating of an ideal flagellum actuated by a collection of motors, including a motor-motor nearest neighbour coupling of strength $K$: when $K$ is small the precision of a large flagellum is much higher than the single motor one. On the contrary, when $K$ is large the two become comparable.