论文标题
疫苗诱导的或杂交免疫与Omicron Wave期间与COVID-19相关的死亡率的关联 - 在老年巴伐利亚人中的回顾性观察性研究
Association of vaccine-induced or hybrid immunity with COVID-19-related mortality during the Omicron wave -- a retrospective observational study in elderly Bavarians
论文作者
论文摘要
背景：缺乏基于人群的研究，就Omicron波过程中SARS-COV-2诱导的免疫保护的有效性和耐用性。方法：这项回顾性研究包括470 159例60岁以上的病例，他们在2022年1月1日至6月30日在德国巴伐利亚州的1月1日至6月30日之间对SARS-COV-2进行了阳性。我们检查了死亡时间，该时间是从报告/症状发作的最早日期到第60天衡量的。COX模型用于估计性别，年龄，最早的记录感染日历日期以及疫苗诱导的或杂交免疫（LI）的调整危险比（HR）。结果：我们观察到3836例死亡（病例死亡率0.82％）。所有LI的死亡风险均明显低于未接种疫苗的情况（在过去六个月内实现了全部原发性LI的调整后的HR：0.30，95％置信区间（CI）0.23-0.39;六个月后：0.46，95％CI 0.35-0.60）。提升进一步降低了死亡的风险（在过去三个月内：HR 0.17，95％CI 0.15-0.20;三个月后：HR 0.25，95％CI 0.21-0.29）。结论：在老年巴伐利亚人中，越来越多的LI与Omicron波浪中对死亡的越来越多相关。但是，几个月后的保护可能会在一定程度上减少。
Background: There is a lack of population-based studies on the effectiveness and durability of the SARS-CoV-2-induced immune protection during the Omicron wave. Methods: This retrospective study included 470 159 cases aged 60 years or older, who tested positive for SARS-CoV-2 between January 1 and June 30, 2022 in Bavaria, Germany. We examined time to death, measured from the earliest date of reporting/symptom onset until day 60. Cox models were used to estimate adjusted hazard ratios (HR) for sex, age, earliest calendar date of documented infection, and level of vaccine-induced or hybrid immunity (LI). Results: We observed 3836 deaths (case fatality rate 0.82%). Risk of death was significantly lower in all LIs than in unvaccinated cases (adjusted HR for a full primary LI achieved within the last six months: 0.30, 95% confidence interval (CI) 0.23-0.39; after six months: 0.46, 95% CI 0.35-0.60). Boosting further decreased the risk of death (within the last three months: HR 0.17, 95% CI 0.15-0.20; after three months: HR 0.25, 95% CI 0.21-0.29). Conclusion: In elderly Bavarians, an increasing LI was associated with an increasing protection against death during the Omicron wave. Protection, however, may decrease to some extent after several months.
