论文标题
从声学到超声频率的超宽带光学相干弹性
Ultra-wideband optical coherence elastography from acoustic to ultrasonic frequencies
论文作者
论文摘要
通过非侵入性成像可视化弹性波，对于分析材料和组织的机械性能很有用。然而，由于对小振动和有限成像速度的有限敏感性，弹性图的最大波频率已限制为〜10 kHz。在这里，我们提出了一种光学相干弹性学技术，该技术将频率范围扩展到MHz，通过降低降噪，抗稳定性解调和高级波分析。我们的系统可以测量硬（GPA）材料的刚度，包括具有MM尺度分辨率的骨骼，并表征从100 Hz到1 MHz的软粘弹性材料。雷利表面波在宽频率范围内的分散使我们能够在软骨前体内介绍深度依赖的剪切模量（10 kPa至100 mpa），体内和人体皮肤在体内。该技术为以3维分辨率的原位表征材料打开了一个新窗口。
Visualizing elastic waves by noninvasive imaging has been useful for analyzing the mechanical properties of materials and tissues. However, the maximum wave frequency of elastography has been limited to ~10 kHz due to the finite sensitivity to small vibration and finite imaging speed. Here, we present an optical coherence elastography technique that extends the frequency range to MHz by noise reduction, anti-aliasing demodulation, and advanced wave analysis. Our system can measure the stiffness of hard (GPa) materials including bones with mm-scale resolution and characterize soft, viscoelastic materials from 100 Hz to 1 MHz. The dispersion of Rayleigh surface waves over the wide frequency range allowed us to profile depth-dependent shear modulus (10 kPa to 100 MPa) in cartilages ex vivo and the human skin in vivo. This technique opened a new window for the characterization of materials in situ with 3-dimensional resolution.
