论文标题
基因型 - 表型相互关系进化的双重复制理论
Double-replica theory for evolution of genotype-phenotype interrelationship
论文作者
论文摘要
基因型与表型之间的关系在确定生物系统的功能和鲁棒性方面起着至关重要的作用。在这里,进化通过基因型的变化发展,而选择基于表型,基因型 - 表型关系也会发展。与基因型确定的适应性景观下的进化相反,这种表型进化的理论仍然发达。在这里,我们通过引入基因型和表型的副本来提供此问题的统计形态。我们将其应用于一个进化模型,其中表型由自旋构型给出。基因型是对旋转的相互作用矩阵,可以给予哈密顿量,并且适应性仅取决于称为目标的旋转子集的构型。我们通过我们的新方法来描述该模型中噪声的遗传变异和表型方差之间的相互作用,该方法扩展了旋转玻璃的复制理论,以包括表型的自旋复制和基因型的耦合 - 固定性。在此框架内,我们获得了针对噪声和选择压力的进化表型的相图,其中每个相都由基因型和表型的适应性和重叠来区分。在这些阶段中,在噪声的中间水平(温度)下实现了与生物进化相关的稳健拟合相,由于复制对称性,噪声和遗传突变的鲁棒性相关。我们还发现,保持表型的高健身水平与获取强大的基因模式以及这种权衡对功能(目标)部分与其余非功能(非功能性(非目标)的尺寸之间的比率的依赖性之间的权衡。实现高适应性所需的选择压力随着目标旋转的比例增加。
The relationship between genotype and phenotype plays a crucial role in determining the function and robustness of biological systems. Here the evolution progresses through the change in genotype, whereas the selection is based on the phenotype, and genotype-phenotype relation also evolves. Theory for such phenotypic evolution remains poorly-developed, in contrast to evolution under the fitness landscape determined by genotypes. Here we provide statistical-physics formulation of this problem by introducing replicas for genotype and phenotype. We apply it to an evolution model, in which phenotypes are given by spin configurations; genotypes are interaction matrix for spins to give the Hamiltonian, and the fitness depends only on the configuration of a subset of spins called target. We describe the interplay between the genetic variations and phenotypic variances by noise in this model by our new approach that extends the replica theory for spin-glasses to include spin-replica for phenotypes and coupling-replica for genotypes. Within this framework we obtain a phase diagram of the evolved phenotypes against the noise and selection pressure, where each phase is distinguished by the fitness and overlaps for genotypes and phenotypes. Among the phases, robust fitted phase, relevant to biological evolution, is achieved under the intermediate level of noise (temperature), where robustness to noise and to genetic mutation are correlated, as a result of replica symmetry. We also find a trade-off between maintaining a high fitness level of phenotype and acquiring a robust pattern of genes as well as the dependence of this trade-off on the ratio between the size of the functional (target) part to that of the remaining non-functional (non-target) one. The selection pressure needed to achieve high fitness increases with the fraction of target spins.